Endocrine Abstracts

Aim: To evaluate sleep architecture of patients with Cushing’s disease (CD) and to explore whether agouti-related peptide (AgRP) leptin, and interleukin-6 (IL-6) play a permissive role in sleep alterations.Methods: We performed polysomnography on 26 patients with active CD and age 26 age- and sex-matched control subjects. Blood samples were obtained from all participants for the analyses of AgRP, leptin, and IL-6. The laboratory and sleep-related pa...

Aim: To investigate the volumetric changes in cortical and subcortical deep gray matter (GM) structures and cognitive alterations in patients with mild autonomous cortisol secretion (MACS). We also sought to assess whether the anticipated changes in brain volume and cognitive functions of the patients with MACS differ from the changes in patients with overt Cushing’s Syndrome (CS). Methods: In this cross-sectional study, volumes of the cortex, hippo...

Approximately 20 percent of the world’s working population is working shifts. The shift working system that affects such a large population often causes circadian rhythm disturbances. These disorders adversely affect nutritional habits and quality, sleep patterns and quality, and body composition. The risk of chronic diseases, especially obesity and diabetes, increases due to the direct and indirect effects of disruption in the circadian rhythm. The aim of this study is ...

Aim: Image-guided thermal ablation methods are gaining popularity in recent years for the treatment of benign and malignant thyroid nodules. It has also started to be performed more frequently in our country in the last few years, but few centers have published data on this subject. We aimed to assess the effectiveness and safeness of microwave ablation (MWA) technique in patients with benign thyroid nodules (TNs).Materials and Methods: This retrospectiv...

Introduction: Hypervitaminosis D is a rarely reported condition. It may be observed more frequently because of the recent increase in supplement use of vitamin D. Herein, we report a case of vitamin D intoxication which was the first case with this high level of calcium as we searched the literature.Case report: A 57-year old hypertensive woman admitted to our emergency room with symptoms of constipation, loss of appetite and confusion. Blood pressure, h...

Cancer metastases on pituitary gland are seen rarely. A 71-year-old male was admitted to Endocrinology Department with polydipsia, polyuria, and diplopia. Urine volume was ~5 l/day. In medical history; he had been diagnosed as having non-small cell lung carcinoma with multiple liver and bone metastases 1 year ago. He took chemotherapies with four cycles of paclitaxel, carboplatin, and zoledronic acid for bone metastases and radiation therapy (RT) was given to L4-S1 vertebras. ...

Langerhans cell histiocytosis (LCH) is a disease with monoclonal proliferation and infiltration of organs by Langerhans cell. LCH is commonly seen in the skeletal system and skin, but it may also involve paranchymal organs. Thyroid involvement in LCH is unusual, and coexistence of thyroid with lung involvement is seen very rare. Here we present a patient with LCH, who has thyroid and lung involvement.Case: A 26-old woman, who had LCH of the lung was refe...

Objective: Hyperprolactinemia is a rare endocrine disorder in childhood, which may be due to various etiological factors and may present with different signs and symptoms. We aimed to evaluate the etiologic reasons, clinical features and outcome in hyperprolactinemia patients retrospectively.Method: Data from 25 patients who were followed up with hyperprolactinemia between years 2009 and 2017 were evaluated.Results: A total of 25 p...

Aim: To identify the causes and predictors of mortality in acromegaly patients diagnosed, treated, and followed in the Pituitary Center of Istanbul University-Cerrahpasa over the last three decades using machine learning (ML) models.Methods: The study sample consisted of 607 consecutive patients diagnosed with acromegaly at Cerrahpasa Faculty of Medicine during the period 1990 – 2023. The main inclusion criteria were age > 18 years and a clear-c...

Objective: To determine the frequency of polycystic ovary syndrome (PCOS) in women with prediabetes compared to control women.Methods: Digital screening and tele-interviews remotely excluded 3218 out of 3465 consecutive women applied for routine check-up. In-person assessments were performed on 247 women, excluding 49. Final analyses included 198 premenopausal women without endocrine disorders (other than prediabetes and PCOS) or conditions affecting gon...